Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5274877 | Tetrahedron Letters | 2008 | 4 Pages |
Abstract
An efficient method for the synthesis of disubstituted thioureas via the reaction of N,Nâ²-di-Boc-substituted thiourea 5 with alkyl and aryl amines under mild conditions has been developed. In the presence of NaH as a base, trifluoroacetic anhydride (TFAA) reacted with 5 providing intermediate 6, which then reacted with amines giving thioureas 7 in excellent yields. This reaction conditions tolerated other functional groups such as amide, ester, enol ether and hydroxyl groups.
Graphical abstractAn efficient method for the synthesis of disubstituted thioureas via the reaction of N,Nâ²-di-Boc-substituted thiourea with alkyl and aryl amines under mild conditions has been developed.Download full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Biaolin Yin, Zhaogui Liu, Mingjun Yi, Jiancun Zhang,