Article ID Journal Published Year Pages File Type
5274877 Tetrahedron Letters 2008 4 Pages PDF
Abstract

An efficient method for the synthesis of disubstituted thioureas via the reaction of N,N′-di-Boc-substituted thiourea 5 with alkyl and aryl amines under mild conditions has been developed. In the presence of NaH as a base, trifluoroacetic anhydride (TFAA) reacted with 5 providing intermediate 6, which then reacted with amines giving thioureas 7 in excellent yields. This reaction conditions tolerated other functional groups such as amide, ester, enol ether and hydroxyl groups.

Graphical abstractAn efficient method for the synthesis of disubstituted thioureas via the reaction of N,N′-di-Boc-substituted thiourea with alkyl and aryl amines under mild conditions has been developed.Download full-size image

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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