| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5274878 | Tetrahedron Letters | 2008 | 6 Pages |
Abstract
Carbonic acid diesters have been investigated as carbonylating agents in the direct reaction with pyrrole (HetNH). In the presence of superbases (DBU, P1-t-Bu, BTPP) as catalysts, the heteroaromatic substrate can be N-carbonylated by direct reaction with carbonic acid diesters under not-severe experimental conditions. The carbonylation reaction makes accessible pyrrole N-carbonyl derivatives (HetNC(O)OR, (HetN)2CO) selectively through a simple straightforward way, which offers a safe eco-friendly alternative to the traditional synthetic methods based on hazardous phosgene or phosgene-derivatives.
Graphical abstractOrganic carbonates have been studied as carbonylating agents in the direct reaction with pyrrole.Download full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Marianna Carafa, Monica Distaso, Valentina Mele, Francesca Trani, Eugenio Quaranta,