| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5274941 | Tetrahedron Letters | 2007 | 4 Pages |
Abstract
A simple two-step procedure for the conversion of readily available phthalides to the corresponding benzoxazinones was developed. Initial ring-opening aminolysis to form a primary 2-hydroxymethylbenzamide, followed by reaction with bis(trifluoroacetoxy)iodobenzene (BTI) conveniently, provided a variety of 4-substituted benzoxazinones.
Graphical abstractA two-step procedure for the synthesis of benzoxazinones from phthalides was developed.Download full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Synthesis of 1,4-dihydro-benzo[d][1,3]oxazin-2-ones from phthalides via an aminolysis-Hofmann rearrangement protocol](/preview/png/5274941.png "First Page Preview: Synthesis of 1,4-dihydro-benzo[d][1,3]oxazin-2-ones from phthalides via an aminolysis-Hofmann rearrangement protocol")
Authors
Eliud Hernández, Jessica M. Vélez, Cornelis P. Vlaar,