Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5274976 | Tetrahedron Letters | 2011 | 5 Pages |
Abstract
Bromophenyl magnesium reagents generated via a Knochel type magnesium-halogen exchange of aryl iodides undergo regioselective ring opening of cyclic primary and secondary N-Boc sulfamidates in good to excellent yields. With secondary sulfamidates the reaction proceeds with clean inversion of the stereochemistry. This protocol complements the ring opening of aziridines with bromophenyl metal reagents and extends its scope to secondary substrates.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Paul Hebeisen, Urs Weiss, André Alker, Andreas Staempfli,