| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5274988 | Tetrahedron Letters | 2011 | 4 Pages |
Abstract
Enzymatic epoxide-opening cascade is one of the key biosynthetic processes for constructing structurally diverse polyethers. Here we report the first in vitro analysis of the cyclization catalyzed by two epoxide hydrolases, MonBI and MonBII involved in monensin biosynthesis, using simple epoxy-alcohols and the unprecedented synergistic effect on the epoxide-opening activity between these epoxide hydrolases.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kyohei Sato, Atsushi Minami, Toyoyuki Ose, Hiroki Oguri, Hideaki Oikawa,