Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5275007 | Tetrahedron Letters | 2011 | 4 Pages |
Abstract
A novel biocatalytic method for the enantioselective synthesis of (R)-bromo-3-[4-(2-methoxy-ethyl) phenoxy]-2-propanol [(R)-BMEPP], a precursor for the synthesis of (S)-metoprolol, an anti hypertensive drug is described. We have developed kinetic resolution of rac-BMEPP by transesterification using Candida rugosa lipase and vinyl acetate as the acyl donor affording the product with excellent conversion (49%) and ee (>99%). Various reaction parameters (source of enzyme, reaction media, and concentration of substrate and acylating agent) for the enzymatic kinetic resolution have been reported.
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Authors
Abhishek Kaler, Vachan Singh Meena, Manpreet Singh, Brahmam Pujala, Asit K. Chakraborti, Uttam Chand Banerjee,