| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5275008 | Tetrahedron Letters | 2011 | 4 Pages |
Abstract
The preparation of 2-(arylmethoxy)isopinocampheols from pinanediol via the DIABL-H reduction of the corresponding aryl aldehyde acetals has been described. A systematic examination of the asymmetric aldol reaction of 3,3,3-trifluoropropionates led to the double diastereoselective aldol reaction of 2-(arylmethoxy)isopinocampheyl 3,3,3-trifluoropropionates providing anti-α-trifluoromethyl-β-hydroxy esters in 63-85% yields, ⩾99% anti-selectivity and 80-96% de for the anti-isomer.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
P. Veeraraghavan Ramachandran, Gowrisankar Parthasarathy, Pravin D. Gagare,