Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5275040 | Tetrahedron Letters | 2009 | 4 Pages |
Abstract
An original two-step process for the synthesis of [1,4]oxazepin-2-ones starting from Baylis-Hillman (BH) adducts is reported. The protocol involves a nucleophilic substitution of the acetates of BH adducts with renewable natural α-amino esters followed by base-catalyzed intramolecular Michael addition. These sequential reactions are operationally simple, performed under ambient conditions, and give 81-93% yields of the target [1,4]oxazepin-2-ones. Thus, the present invention opens up a new aspect for the synthetic utility of BH adducts.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Lal Dhar S. Yadav, Vishnu P. Srivastava, Rajesh Patel,