| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5275086 | Tetrahedron Letters | 2008 | 5 Pages |
Abstract
The first total synthesis of mycestericin A (1) starting from tartrates is described. The Overman rearrangement of an allylic trichloroacetimidate generated a tetra-substituted carbon with nitrogen, and subsequent stereoselective transformations afforded the highly functionalized vinyl iodide. The cross-coupling of the vinyl iodide with a chiral organozinc species under Negishi conditions, followed by deprotection, completed the total synthesis of 1.
Graphical abstractThe first total synthesis of mycestericin A (1) starting from tartrates is described.Download full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hideyuki Sato, Kazuya Sato, Masatoshi Iida, Hiroyoshi Yamanaka, Takeshi Oishi, Noritaka Chida,