| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5275101 | Tetrahedron Letters | 2009 | 5 Pages |
Abstract
Five-membered heterocyclic ureas are capable of forming the unfolded conformer without preorganization by using the intramolecular hydrogen bond, and are suitable for the DDA hydrogen-bonding modules. In contrast, six-membered heterocyclic ureas are destabilized by an effect of steric repulsion due to the closer distance of CHcâ¯O and their conformational equilibriums are biased toward the stable folded conformer.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yosuke Hisamatsu, Yuki Fukumi, Naohiro Shirai, Shin-ichi Ikeda, Kazunori Odashima,