Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5275120 | Tetrahedron Letters | 2007 | 4 Pages |
Abstract
A new bromohexyl phosphoramidite was synthesized and used for the introduction of an azide function at the 5â²-end of oligonucleotides after a treatment on solid support with sodium azide and sodium iodide. The corresponding 5â²-azido oligonucleotide could be further used for 'Click' conjugation with alkyne derivatives or by Staudinger ligation.
Graphical abstractA new phosphorylating reagent for chemical 5â²-azidation of oligonucleotides.Download full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jory Lietard, Albert Meyer, Jean-Jacques Vasseur, François Morvan,