| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5275135 | Tetrahedron Letters | 2007 | 4 Pages |
Abstract
Two novel dimeric meroterpenoids, bisbakuchiols A and B, along with (S)-bakuchiol were isolated from the seeds of Psoralea corylifolia L. (Fabaceae). Bisbakuchiols A and B contain an unprecedented dimeric meroterpenoid skeleton in which two meroterpenes are linked through a dioxane bridge. All compounds were evaluated for their potential to inhibit hypoxia-inducible factor-1 (HIF-1) activation induced by hypoxia in a HIF-1-mediated reporter gene assay in AGS human gastric cancer cells. (S)-Bakuchiol inhibited hypoxic activation of HIF-1 with an IC50 value of 6.1 μM.
Graphical abstractTwo novel dimeric meroterpenoids, bisbakuchiols A and B, were isolated from the seeds of Psoralea corylifolia.Download full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Cheng-Zhu Wu, Xing Fu Cai, Nguyen Tien Dat, Seong Su Hong, Ah-Reum Han, Eun-Kyoung Seo, Bang Yeon Hwang, Ji-Xing Nan, Dongho Lee, Jung Joon Lee,