Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5275151 | Tetrahedron Letters | 2007 | 5 Pages |
Abstract
A new route to abietane and podocarpane-type terpenoids from labdane diterpenes is reported. The key step is the transformation of β-ketoester 9 into the corresponding O-acetylsalicylate ester 18, via a manganese(III)-based oxidative free-radical cyclization carried out in Ac2O. Utilizing this, the synthesis of the antitumor (+)-7-deoxynimbidiol (5) from (â)-sclareol (11) has been achieved. (+)-Nimbidiol (6) and the natural terpenoid 20 have also been synthesized.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Enrique Alvarez-Manzaneda, Rachid Chahboun, Eduardo Cabrera, Esteban Alvarez, Ramón Alvarez-Manzaneda, Mohammed Hmamouchi, Hakima Es-Samti,