| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5275160 | Tetrahedron Letters | 2012 | 4 Pages |
Abstract
The synthesis and applications of 4-isocyanopermethylbutane-1,1,3-triol (IPB) as a new convertible isonitrile (isocyanide) for isocyanide-based multicomponent reactions (IMCRs) like Ugi, Ugi-Smiles, and Passerini reactions are described. The primary products obtained from these IMCRs can be converted into highly activated N-acylpyrroles, which upon treatment with nucleophiles can be transformed into carboxylic acids, esters, amides, alcohols, and olefins. In this sense the reagent can be seen as a neutral carbanion equivalent to formate (HO2Câ), and carboxylates or carboxamides etc. (RNu-COâ).
Related Topics
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Authors
Ricardo A.W. Neves Filho, Sebastian Stark, Micjel C. Morejon, Bernhard Westermann, Ludger A. Wessjohann,