Synthesis of bis(indolyl)methanes using silica gel as an efficient and recyclable surface

Here we describe a simple, clean, and efficient solvent-free protocol for the synthesis of bis(indolyl)methanes promoted by silica gel. The products were obtained in good to excellent yields through the reaction of indoles with cyclohexanone and a range of aldehydes. The silica gel was easily recovered and utilized for further reactions without loss of activity.

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