| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5275230 | Tetrahedron Letters | 2011 | 8 Pages |
Abstract
Condensation reactions of o-phenylenediamine and 2Â equiv of acetone produce biaryl-substituted 1,5-benzodiazepines. The synthetic protocol shows general applicability since similar reaction of o-phenylenediamines, o-aminophenol, and o-aminothiophenol with ketones or chalcones leads to formation of functionalized 1,5-benzoheteroazepines in good to excellent yields. The synthetic protocol fulfills many green-chemical requirements using simple MW-assistance to promote the activation of ketones and the eco-compatible Er(III) triflate as activator of chalcones.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Monica Nardi, Annalisa Cozza, Loredana Maiuolo, Manuela Oliverio, Antonio Procopio,