| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5275285 | Tetrahedron Letters | 2008 | 4 Pages |
Abstract
Two routes for the synthesis of potent BCRP inhibitor-Ko143 are reported. The key intermediate, 6-methoxytryptophan derivative, was synthesized by an improved procedure, ytterbium triflate-promoted coupling between 6-methoxyindole and optically active 1-benzyl-2-methyl-(S)-1,2-aziridinecarboxylate in the second protocol.
Graphical abstractA new protocol for the synthesis of potent BCRP inhibitor-Ko143.Download full-size image
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yuexian Li, Erik Hayman, Mihaela Plesescu, Shimoga R. Prakash,