| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5275326 | Tetrahedron Letters | 2007 | 4 Pages |
Abstract
The aim of this study was to develop a practical route for preparing a fluorine-18 ([18F]) labelled ligand ([18F]1) containing [18F]fluorobenzene ring by employing the reaction of diphenyliodonium salt with [18F]Fâ. Diphenyliodonium tosylate (2) was synthesized from tributylphenylstannyl compound (6) with [hydroxy(tosyloxy)iodo]benzene (7). Using this method, [18F]DAA1106 ([18F]3a), a positron emission tomography ligand for imaging peripheral-type benzodiazepine receptor, was prepared.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
![A practical route for synthesizing a PET ligand containing [18F]fluorobenzene using reaction of diphenyliodonium salt with [18F]Fâ](/preview/png/5275326.png "First Page Preview: A practical route for synthesizing a PET ligand containing [18F]fluorobenzene using reaction of diphenyliodonium salt with [18F]Fâ")
Authors
Ming-Rong Zhang, Katsushi Kumata, Kazutoshi Suzuki,