Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5275331 | Tetrahedron Letters | 2007 | 4 Pages |
Abstract
Highly enantiomerically enriched β-aminoalkanamides 12 and β-phenylaminoalkanamides 13 have been prepared by the addition reaction of α-lithiated 2-alkyl-2-oxazolines 9-Li, derived from optically active oxazolines 9, to N-cumyl nitrones 2. The relative stereochemistry of alkanamides 5 and 6 has been established by 1D-NOESY experiments carried out on the related pyrimidinones 7, whereas the absolute configuration of alkanamides 12 and 13 has been confirmed by an X-ray analysis.
Graphical abstractDownload full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Vito Capriati, Leonardo Degennaro, Saverio Florio, Renzo Luisi, Corrado Cuocci,