| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5275332 | Tetrahedron Letters | 2007 | 6 Pages |
Abstract
Aromatic compounds bearing a basic nitrogen atom can be converted to the corresponding nitric acid salts. Mono-nitration of the compounds can be carried out by adding a dichloromethane solution of the salts to sulfuric acid, or by adding acetyl chloride (or trifluoroacetic anhydride) to a dichloromethane solution of the salts. This protocol provides, among other benefits, the most convenient and reliable way for the prevention of over-/under-nitration and is especially suitable for scale-up.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Pingsheng Zhang, Miall Cedilote, Thomas P. Cleary, Michael E. Pierce,