Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5275341 | Tetrahedron Letters | 2007 | 4 Pages |
Abstract
A general catalytic addition of nitromethane to simple N-diphenylphosphinoyl ketimines is achieved using either 10 mol % 1,1,3,3-tetramethylguanidine (TMG) or 10 mol % phosphazene (t-Bu-P1) as organic base catalysts in good to high yields. On the other hand, N-sulfinylketimines also furnished the aza-Henry product in good yield with moderate diastereoselectivity (3:1). Thus, the methodology developed here is a good template for developing the first organocatalytic approach towards the aza-Henry reaction of ketimines.
Graphical abstractDownload full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Nirmal K. Pahadi, Hitoshi Ube, Masahiro Terada,