| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5275387 | Tetrahedron Letters | 2012 | 4 Pages |
Abstract
We describe herein shelf-stable, isolable, and characterizable pyridyl lithium trihydroxy and triisopropoxy 2-borate salts (LTBS) for use in modified Suzuki-Miyaura cross-coupling reactions that can be produced in quantities greater than one hundred grams. Pyridyl LTBS provide a viable cross-coupling alternative to unstable 2-pyridylboronic acids, boronates, and trifluoroborate salt derivatives. We also demonstrate the synthesis and cross-coupling of shelf-stable LTBS reagents of other sp2-hybridized nitrogen-containing heterocycles including thiazole, pyrazine, quinoline, and isoquinoline heterocycles.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kuanchiang Chen, Richard Peterson, Shivanand K. Math, James B. LaMunyon, Charles A. Testa, Dustin R. Cefalo,