| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5275402 | Tetrahedron Letters | 2011 | 5 Pages |
Abstract
This study investigates the ability of the mixed-metal reagent [Li(TMP)Zn(tBu)2] 1 to promote direct Zn-H exchange reactions (zincations) of a wide range of N-heterocyclic molecules. The generated metallated intermediates from these reactions are intercepted with I2 and some of them are also employed as precursors in Pd-catalysed Negishi cross-coupling applications. A comparison with recent precedents in metallation chemistry reveals that for some of these heterocycles, 1 allows improved conversions, under milder conditions and in certain cases, even gives unique regioselectivities.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Victoria L. Blair, David C. Blakemore, Duncan Hay, Eva Hevia, David C. Pryde,