| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5275417 | Tetrahedron Letters | 2011 | 4 Pages |
Abstract
C-H Nitrooxylation at benzylic positions has been achieved by employing the N-hydroxyphthalimide (NHPI) catalyst/cerium(IV) ammonium nitrate (CAN) reagent system. The nitrooxy groups were demonstrated to function as tentative hydroxy protecting groups, as well as excellent leaving groups for N- and C-substitution reactions. Hence, the present method offers a unique way to synthesize diverse O-, N-, or C-functionalized benzylic compounds from simple alkyl aromatics.
Graphical abstractDownload full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Shin Kamijo, Yuuki Amaoka, Masayuki Inoue,