| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5275488 | Tetrahedron Letters | 2008 | 4 Pages |
Abstract
Thiophene derivatives with multiple substitutions are prepared from vinylidene bromide, which is synthesized by the reaction of thiophene-2-carboxaldehyde with carbon tetrabromide in the presence of PPh3, as a core molecule through several coupling reactions such as Suzuki-Miyaura coupling and palladium-catalyzed CH arylation. The reactions with a wide variety of organic halides lead to a series of substituted thiophene derivatives in moderate to good yields.
Graphical abstractThiophene derivatives with multiple substitutions are prepared from vinylidene bromide with Suzuki-Miyaura coupling and palladium-catalyzed CH arylation.Download full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Nobumichi Arai, Takayuki Miyaoku, Shota Teruya, Atsunori Mori,