Various P∗-chiral phosphite-type ligands: their synthesis, stereochemistry and use in Pd-catalysed allylation

A new family of readily available modular phosphite, phosphoramidite and diamidophosphite ligands with P∗-stereocentres have been prepared from inexpensive optically active precursors. Using these novel ligands, up to 91% ee was achieved in Pd-catalysed asymmetric allylic amination. The catalytic performance is affected greatly by the structure of the phosphocentre of the ligand.

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