Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5275552 | Tetrahedron Letters | 2007 | 4 Pages |
Abstract
Two new imidazo[1,2-a]pyridine derivatives, pyridinoimidazo[1,2-a]pyridine (10) and pyrroloimidazo[1,2-a]pyridine (16), were synthesised from 2-amino-4-methyl-5-nitropyridine (1) by linear cyclisation, making use of dimethylformamide dimethylacetal (DMFDMA) as an agent of vinylamine functionalisation. This report describes first the formation of pyridine and pyrroloimidazopyridine from (1), and then the formation of pyridine-fused and pyrrolo-fused pyridine by the Friedländer method and reductive cyclisation followed by treatment of the resulting adduct with chloroacetaldehyde.
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Organic Chemistry
Authors
Mounir Andaloussi, Emmanuel Moreau, Olivier Chavignon, Jean C. Teulade,