| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5275574 | Tetrahedron Letters | 2012 | 4 Pages |
Abstract
The highly diastereoselective synthesis of the marine natural product, (â)-manzacidin B, is described. A novel copper-catalyzed aldol reaction of the α-methylserine-derived aldehyde with an isocyanoacetate possessing (1R)-camphorsultam as the chiral auxiliary proceeded in a highly diastereoselective manner to give the (4R,5R,6R)-adduct, which was converted into manzacidin B in a few steps.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Tetsuro Shinada, Kentaro Oe, Yasufumi Ohfune,