Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5275608 | Tetrahedron Letters | 2012 | 4 Pages |
Abstract
A series of oxacyclic diene compounds, especially eight-membered products bearing a single oxygen atom which have not been reported previously, were successfully synthesized via ring-closing enyne metathesis using the second-generation Grubbs catalyst. In contrast to the construction of the five-membered rings, completely opposite substrate selectivity that methyl substituted internal alkyne showed much higher reactivity than terminal alkyne was observed in building eight-membered ring derivatives.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Lin-Lin Zhang, Wen-Zhen Zhang, Xiang Ren, Xin-Yan Tan, Xiao-Bing Lu,