| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5275618 | Tetrahedron Letters | 2011 | 4 Pages |
Abstract
Treatment of 4-, 3- or 2-aryl-4,5-diphenyloxazolines with isopropyllithium gives the products of dearomatising addition, fluorine-directed lithiation or nucleophilic aromatic substitution of fluoride depending on substitution pattern and conditions. In the case of the 4-fluoroaryl substrates, fluorinated 1,4-cyclohexadiene may be obtained in good yield.
Graphical abstract2-, 3- and 4-Fluoroaryloxazolines show varying reactivity towards organolithiums, undergoing either substitution, metallation or addition reactions.Download full-size image
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Authors
James Clayton, Jonathan Clayden,