Synthesis of novel furo-pyran derivatives via reaction between an isocyanide and alkylidene-substituted Meldrum’s acid

An unexpected four-component (3+1) reaction of an alkyl isocyanide with alkylidene-substituted Meldrum’s acid in CH2Cl2 at room temperature produces imino-furopyranones in good yields. The structures of the products are deduced from their IR, 1H NMR, and 13C NMR spectra and by X-ray analysis. The products are structurally similar to 2H-furo[2,3-c]pyran-2-one natural products.

Graphical abstractA four-component (3+1) reaction of alkyl isocyanides with alkylidene-substituted Meldrum’s acid produces new imino-furopyranone derivatives. The products are structurally similar to 2H-furo[2,3-c]pyran-2-one natural products.Figure optionsDownload full-size imageDownload as PowerPoint slide