Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5275779 | Tetrahedron Letters | 2012 | 4 Pages |
Abstract
Organocatalytic asymmetric Michael addition of 3-(OTBS)-propanal to β-nitrostyrenes catalyzed by chiral sulfamides was investigated. Good d.r. (up to 80:20) and excellent enantioselectivities (up to >99% ee) were achieved. Both the N-[(1R,2R)-2-aminocyclohexyl]-N'-(phenylmethyl)sulfamide 7b and the novel chiral N-[(1R,2R)-2-aminocyclohexyl]-N'-[3,5-bis(trifluoromethyl)phenyl]sulfamide 7a were identified as efficient primary amine organocatalysts.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Simone Tortoioli, Sergio Bacchi, Cecilia Tortoreto, John B. Strachan, Alcide Perboni,