| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5275795 | Tetrahedron Letters | 2012 | 4 Pages |
Abstract
The development of a novel fluorene-type anchor support molecule and a liquid-phase peptide synthesis protocol (AJIPHASE®) is reported. With this support molecule, the synthesis of a protected peptide with a free carboxyl group could be carried out by repeated coupling/deprotection reactions and isolation by simple precipitation. Cleavage is performed under mild acidic conditions (2% TFA/CHCl3 or hexafluoroisopropanol) to release the products in good yield and purity. There were no signs of either diketopiperazine formation or the removal of protective groups in the side-chain.
Graphical abstractDownload full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Daisuke Takahashi, Takashi Yamamoto,