| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5275828 | Tetrahedron Letters | 2009 | 4 Pages |
Abstract
A simple chiral derivatisation protocol for determining the enantiopurity of O-silyl-protected-1,2-amino alcohols by 1H NMR spectroscopic analysis is described, which involves their treatment with 2-formylphenylboronic acid and enantiopure (syn)-methyl-2,3-dihydroxy-3-phenylpropionate to afford mixtures of imino-boronate esters whose diastereoisomeric ratio is an accurate reflection of the enantiopurity of the parent amino alcohol.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Magdalena E. Powell, Andrew M. Kelly, Steven D. Bull, Tony D. James,