| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5275840 | Tetrahedron Letters | 2009 | 4 Pages |
Abstract
The easily prepared chiral tertiary amino alcohol 1a was found to catalyze the reaction of alkynylzinc reagents with various aldehydes to generate chiral propargylic alcohols with moderate-to-good enantioselectivities. The mechanism of the reaction is also discussed in this Letter. A novel theoretical computation of those evaluated ligands was introduced which may supply valuable experience to help designing new chiral ligands.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
