| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5275905 | Tetrahedron Letters | 2007 | 4 Pages |
A series of novel spiro-isoxazoline C-disaccharides were synthesized by the key step of 1,3-dipolar cycloaddition reactions of exo-glycals and sugar nitrile oxides, and followed by catalytic debenzylation in the presence of Pd(OH)2/C. The cycloaddition reactions were carried out stereoselectively and afforded α-isomers exclusively except in the case of galactose. The biological activities of the novel disaccharides against the glycosidases (α-amylase, α-glucosidase, and β-glucosidase) and HIV and BVDV were evaluated.
Graphical abstractA series of novel spiro-isoxazoline C-disaccharides were synthesized by the 1,3-dipolar cycloaddition reactions of exo-glycals to sugar nitrile oxides, and their glycosidase inhibitory and antiviral activities were also evaluated.Download full-size image
