Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5275907 | Tetrahedron Letters | 2007 | 4 Pages |
Starting from trifluoromethyl β-dicarbonyl compounds, a rare loss of CF3CO was observed in the amination reactions performed under heterogeneous conditions using NsONHCO2Et as the aminating agent and CaO or NaH as the base, while corresponding nonfluorinated β-dicarbonyl compounds under analogous conditions give non deacylated aminated compounds. This reaction can facilitate a direct synthesis of N-substituted α-amino esters or α-amino ketones.
Graphical abstractA rare loss of CF3CO was observed in the amination reactions of trifluoromethyl β-dicarbonyl compounds with NsONHCO2Et as the aminating agent and CaO or NaH as the base. The reaction can facilitate a direct synthesis of N-substituted α-amino esters or α-amino ketones.Download full-size image