Article ID Journal Published Year Pages File Type
5275907 Tetrahedron Letters 2007 4 Pages PDF
Abstract

Starting from trifluoromethyl β-dicarbonyl compounds, a rare loss of CF3CO was observed in the amination reactions performed under heterogeneous conditions using NsONHCO2Et as the aminating agent and CaO or NaH as the base, while corresponding nonfluorinated β-dicarbonyl compounds under analogous conditions give non deacylated aminated compounds. This reaction can facilitate a direct synthesis of N-substituted α-amino esters or α-amino ketones.

Graphical abstractA rare loss of CF3CO was observed in the amination reactions of trifluoromethyl β-dicarbonyl compounds with NsONHCO2Et as the aminating agent and CaO or NaH as the base. The reaction can facilitate a direct synthesis of N-substituted α-amino esters or α-amino ketones.Download full-size image

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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