Generation of molecular complexity from cyclooctatetraene: synthesis of a protected 2-(3′-carboxy-2′-benzoylcyclopentyl)glycine

Synthesis of a protected 2-(3′-carboxycyclopentyl)glycine rac-11, possessing four contiguous chiral carbons, was accomplished in six steps (20% yield) from the hydrocarbon cyclooctatetraene.

Graphical abstractSynthesis of a protected 2-(3′-carboxycyclopentyl)glycine rac-11, possessing four contiguous chiral carbons, was accomplished in six steps (20% yield) from the hydrocarbon cyclooctatetraene.Figure optionsDownload full-size imageDownload as PowerPoint slide