Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5275962 | Tetrahedron Letters | 2007 | 4 Pages |
Abstract
1,4-Disubstituted 1,2,3-triazoles are obtained in excellent yields via a three-component coupling of secondary alcohols, alkynes and trimethylsilyl azide (TMSN3). This one-pot reaction occurs through in situ generation of an azide from the alcohol and TMSN3, followed by 1,3-dipolar cycloaddition of the terminal alkyne to afford the corresponding disubstituted triazoles.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
B. Sreedhar, P. Surendra Reddy, V. Rama Krishna,