One-pot organocatalytic domino Michael/α-alkylation reactions: highly enantioselective synthesis of functionalized cyclopentanones and cyclopentanols

A simple, highly enantioselective catalytic route to cyclopentanones is presented. The chiral amine catalyzed domino Michael/α-alkylation reaction gives access to functionalized cyclopentanones in good to high yields with 93 → 99% ee. The products were also reduced with high diastereoselectivity to the corresponding cyclopentanols.

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