Article ID Journal Published Year Pages File Type
5276003 Tetrahedron Letters 2012 5 Pages PDF
Abstract

A straightforward method has been developed for the synthesis of 1-amidomethyl-imidazo[1,2-a]pyridines by Yb(OTf)3 catalyzed three-component reaction of aldehydes, acetamide, and imidazo[1,2-a]pyridines. A series of substituted 3-substituted imidazo[1,2-a]pyridines were synthesized in moderate to good yield (21-74%) under mild reaction condition and the catalyst was recycled for four cycles.

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Physical Sciences and Engineering Chemistry Organic Chemistry
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