Article ID Journal Published Year Pages File Type
5276011 Tetrahedron Letters 2012 5 Pages PDF
Abstract

A series of glycosidic-pyrroloquinolinone based novel building blocks of camptothecin (2a-g) were synthesized via Lewis acid-assisted olefin cross-metathesis reaction using Ti(OiPr)4 30 mol % and 10 mol % of Grubb's second generation catalyst with good to excellent yields. Most of these compounds exhibited significant growth inhibitory effects on all the tested cancer cell lines and three compounds (2c, 2d and 2e) showed potent cytotoxic activity.

Graphical abstractThe synthesis of antitumor active glycosidic-pyrroloquinolinone based novel building blocks of camptothecin via Lewis acid-assisted olefin cross-metathesis reaction.Download full-size image

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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