Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5276043 | Tetrahedron Letters | 2011 | 6 Pages |
Abstract
A rapid, economic, and high yielding methodology has been developed for hydroacylation/reduction of activated ketones by using 1,3-bis(2,4,6-trimethylphenyl)imidazolium chloride as a catalyst in combination with triethylamine. The reaction proceeded at an ambient temperature via generating N-heterocyclic carbene in situ that interacted with the (hetero)aryl aldehyde employed. While the reduction of ketones takes place in MeOH, the hydroacylation process was found to be effective in THF for both electron rich and deficient aldehydes.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
M. Sreenivasulu, K. Arun Kumar, K. Sateesh Reddy, K. Siva Kumar, P. Rajender Kumar, K.B. Chandrasekhar, Manojit Pal,