Straightforward one-pot stereoselective synthesis of substituted tetrahydrofurans from 1,3-butadienes and aldehydes

A new and efficient multicomponent reaction involving a double-allylation sequence is reported. In situ generated bimetallic reagents are prepared from disilane 1 and added onto a range of aliphatic aldehydes to afford a direct access to trisubstituted tetrahydrofurans in good to excellent diastereoselectivity (up to 70%).

Graphical abstractDownload full-size image