| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5276166 | Tetrahedron Letters | 2007 | 5 Pages |
Abstract
A simple, copper-free and efficient catalytic system for the Sonogashira coupling reaction of aryl bromides with terminal alkynes in pure water has been developed. The use of PdCl2/PPh3 in the presence of pyrrolidine allows the coupling reaction to proceed at 120 °C in moderate to excellent yields.
Graphical abstractA simple, copper-free and efficient catalyst system for the Sonogashira coupling reaction of aryl bromides with terminal alkynes in water has been developed. The use of PdCl2/PPh3 in the presence of pyrrolidine allows the coupling reaction to proceed at 120 °C with moderate to excellent yields.Download full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jin Tao Guan, Tan Qing Weng, Guang-Ao Yu, Sheng Hua Liu,