Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5276208 | Tetrahedron Letters | 2012 | 5 Pages |
Abstract
The coupling of propiolic acid with aryl iodides afforded the aryl alkynyl carboxylic acids and aryl alkynes in generally good yields. Aryl alkynyl carboxylic acids were obtained when the reaction was performed in the presence of Pd(PPh3)2Cl2 (2.5 mol %), dppb (5.0 mol %) and DBU (5 equiv) at 50 °C. For the synthesis of the terminal aryl alkynes, the reaction was conducted in the presence of Pd(PPh3)2Cl2 (2.5 mol %), dppb (5.0 mol %), DBU (5.0 equiv), and Cu(acac)2 (10 mol %) at 25 °C for 5 h, and further reacted at 60 °C for 6 h.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kyungho Park, Thiruvengadam Palani, Ayoung Pyo, Sunwoo Lee,