| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5276245 | Tetrahedron Letters | 2012 | 4 Pages |
Abstract
In the present study, the zinc-catalyzed dehydration of a range of in situ generated aldoximes, available by the reaction of aldehydes and hydroxylamine hydrochloride, has been explored. After investigating various reaction parameters, with Zn(OTf)2 an excellent and easily accessible pre-catalyst was obtained. The system was highly active and dehydrated a broad range of aldoximes selectively to the corresponding nitriles under mild reaction conditions.
Graphical abstractDownload full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Stephan Enthaler, Maik Weidauer, Fanny Schröder,