Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5276337 | Tetrahedron Letters | 2007 | 5 Pages |
Abstract
A mild, efficient, and practical method for the one-step synthesis of acyl azides from carboxylic acids using bis(2-methoxyethyl)aminosulfur trifluoride is described. The reaction was easily extended to the synthesis of the corresponding nitriles by the inclusion of phosphorous reagents. The method can be applied to the synthesis of optically active nitriles in high yields, and is compatible with fluorous phosphines.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Cyrous O. Kangani, Billy W. Day, David E. Kelley,