Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5276410 | Tetrahedron Letters | 2007 | 4 Pages |
Abstract
ABT-578, an anti-restenosis agent exists as two isomers, a major pyran form and a minor oxepane form. The existence of the two isomeric forms was established by isolation and equilibration studies under buffered and physiological conditions. Finally their structures were confirmed by converting the major pyran form to the oxepane form by synthesis, isolation, and characterization.
Related Topics
Physical Sciences and Engineering
Chemistry
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Authors
Madhup K. Dhaon, Casey C. Zhou, Sanjay Chemburkar, Howard Morton,