Article ID Journal Published Year Pages File Type
5276422 Tetrahedron Letters 2012 5 Pages PDF
Abstract

Nafion-H and Nafion SAC-13 are efficient solid Brønsted acid catalysts for the preparation of trifluoromethyl ketimines from benzylamines and trifluoromethylated ketones in high yields. A finely tuned benzylimine-benzaldimine rearrangement by facile 1,3-hydrogen shift has been achieved for the formation of fluorinated benzaldimines in high yields by careful optimization of reaction conditions including attempts under microwave conditions and a flow system. These α-trifluoromethylated benzaldimines are efficient precursors for pharmaceutically important α-trifluoromethylated benzylamines, accessed through their direct acid hydrolysis.

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Physical Sciences and Engineering Chemistry Organic Chemistry
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