Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5276422 | Tetrahedron Letters | 2012 | 5 Pages |
Abstract
Nafion-H and Nafion SAC-13 are efficient solid Brønsted acid catalysts for the preparation of trifluoromethyl ketimines from benzylamines and trifluoromethylated ketones in high yields. A finely tuned benzylimine-benzaldimine rearrangement by facile 1,3-hydrogen shift has been achieved for the formation of fluorinated benzaldimines in high yields by careful optimization of reaction conditions including attempts under microwave conditions and a flow system. These α-trifluoromethylated benzaldimines are efficient precursors for pharmaceutically important α-trifluoromethylated benzylamines, accessed through their direct acid hydrolysis.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
G.K. Surya Prakash, Kevin E. Glinton, Chiradeep Panja, Laxman Gurung, Patrice T. Battamack, Béla Török, Thomas Mathew, George A. Olah,